王曉,男,,博士,,二級研究員,,博士生導師
國家百千萬人才工程人選,,國家有突出貢獻中青年專家,,享受國務院特殊津貼專家,,山東省有突出貢獻的中青年專家,,山東省優(yōu)秀科技工作者,國家中藥材產(chǎn)業(yè)技術體系濟南綜合試驗站站長,,山東省中藥化學對照品(標準品)工程技術研究中心主任,。
電話: 0531-82605304;13031748019
E-mail: [email protected]
主要研究方向:
1. 天然產(chǎn)物提取分離及應用,,天然活性成分分析技術研究
2. 中藥質(zhì)量控制與評價
3. 中藥資源高值化開發(fā)利用
先后主持國家自然科學基金項目(面上項目3項,、主任基金1項)、國家重點研發(fā)計劃,、國家中藥材產(chǎn)業(yè)技術體系項目,、國家科技支撐課題、國家863計劃子課題,、國家重大新藥創(chuàng)制項目,、中央本級重大增減支項目、國家質(zhì)檢公益行業(yè)科研專項,、山東省重大科技專項等項目40余項,。獲得國家科技進步二等獎(第5位)、山東省科技進步一等獎(第1位),、山東省科技進步二等獎,、三等獎等獎項20余項。獲授權專利38項,。獲得國家實物標準50余項,。幾年來,以第一作者或通訊作者在Analytica Chimica Acta ,、Food Chemistry,、Journal of Chromatography A、等國內(nèi)外重要刊物發(fā)表論文200余篇,, SCI收錄150余篇,,SCI他引1500余次,首位授權發(fā)明專利26項。主編《高速逆流色譜技術》,、《pH區(qū)帶逆流色譜技術與應用》專著2部,、參編著作3部。
兼任國際逆流色譜技術委員會委員,、中藥資源生態(tài)專業(yè)委員會副主任委員,、國家標準樣品委員會天然產(chǎn)物工作組副組長、中華中醫(yī)藥學會中藥鑒定分會委員,、中藥標準化技術委員會委員、《中國中藥雜志》編委,、《分析儀器》編委等,。
指導研究生情況:從2006年起共培養(yǎng)畢業(yè)碩士研究生80余人,目前在讀博士研究生2人,,碩士研究生10人,。畢業(yè)碩士研究生升入澳門大學、中國中醫(yī)科學院,、北京中醫(yī)藥大學,、中國農(nóng)業(yè)大學、江南大學等知名高校院所攻讀博士學位,,多人次研究生獲得國家獎學金,,1人獲得山東省優(yōu)秀畢業(yè)生。
部分主持科研項目:
1. 國家自然科學基金面上項目“蒸制介導的天麻中巴利森苷化學行為對其品質(zhì)形成的調(diào)控機制研究”
2. 國家自然科學基金面上項目“基于雙重脅迫假說的金銀花干燥過程的褐變機制研究”
3. 國家自然科學基金面上項目“基于可逆絡合反應的高速逆流色譜體系及分離機理研究”
4. 國家自然科學基金主任基金“辣椒干制過程中紅編變機制及調(diào)控”
5. 國家重點研發(fā)計劃“基于生態(tài)系統(tǒng)循環(huán)模式的中藥生態(tài)農(nóng)業(yè)研究與應用”
6. 國家863計劃子課題“藥食同源重要功能因子提取,、分離及規(guī)?;锖铣申P鍵技術研究”
7. 國家科技支撐計劃“栝樓規(guī)范化種植基地及其SOP優(yōu)化升級研究”
8. 國家重大新藥創(chuàng)制項目“中藥與天然藥物活性物質(zhì)高效分離純化單元技術平臺”
9. 中央本級重大增減支項目“中外西洋參品質(zhì)差異及其與根際微生物關系研究”
10. 中央本級重大增減支項目“基于穩(wěn)定同位素分析技術的藥材產(chǎn)地溯源”
11. 國家質(zhì)檢行業(yè)公益性科研專項“重要農(nóng)產(chǎn)品中不同類型標準樣品研究”
12. 國家質(zhì)檢行業(yè)公益性科研專項“基于過程控制的農(nóng)產(chǎn)品購銷服務重要技術標準研究與示范”
13. 山東省自主創(chuàng)新重大科技專項“金銀花資源高值產(chǎn)品開發(fā)”
14. 山東省重點研發(fā)計劃“中藥藥效物質(zhì)標準化制備技術體系研究”
15. 山東省科技發(fā)展計劃項目“中藥化學對照品制備研究技術平臺”
16. 山東省重點研發(fā)計劃“特醫(yī)食品中功能糖高效精準檢測技術和質(zhì)量評價體系研究”
17. 山東省重點研發(fā)計劃“基于功效的道地金銀花藥材質(zhì)量評價體系研究”
18. 山東省農(nóng)業(yè)重大應用技術創(chuàng)新項目“出口蔬菜重點危害物質(zhì)高效識別和確證關鍵技術研究與示范”
部分代表性研究論文
1. Chenglong Sun,F(xiàn)ukai Wang,,Yang Zhang,,Jinqian Yu,Xiao Wang *,Mass spectrometry imaging-based metabolomics to visualize the spatially resolved reprogramming of carnitine metabolism in breast cancer,,Theranostics,,2020,1126, 82-137 (IF = 8.579)
2. Chenglong Sun,,Wei Liu,,Yanling Geng,Xiao Wang *, On-Tissue Derivatization Strategy for Mass Spectrometry Imaging of Carboxyl-Containing Metabolites in Biological Tissues, Analytical Chemistry, 2020,1126, 82-138 (IF = 6.785)
3. Yanhu Wang,Huihui Shi,Lina Zhang,Shenguang Ge,,Meiling Xu,,Xiao Wang *,Jinghua Yu.Two-dimensional black phosphorus nanoflakes: A coreactant-free electrochemiluminescence luminophors for selective Pb2+ detection based on resonance energy transfer, Journal of Hazardous Materials,2020, 1126, 82-141(IF = 9.038)
4. Wenhua Ji, Rihan Sun, Yanling Geng, Wei Liu, Xiao Wang *, Rapid, low temperature synthesis of molecularly imprinted covalent organic frameworks for the highly selective extraction of cyano pyrethroids from plant samples, Analytica Chimica Acta, 2018, 1001, 179–188. (IF = 5.1, top期刊)
5. Wenhua Ji, Yushuang Guo, Xiao Wang*, Dianshun Guo*, A water-compatible magnetic molecularly imprinted polymer for the selective extraction of risperidone and 9-hydroxyrisperidone from human urine, Talanta, 2018, 181, 392–400. (IF = 4.2)
6. Wenhua Ji, Mingming Zhang, Tao Wang, Xiao Wang*, Zhenjia Zheng, Junjie Gong. Molecularly imprinted solid-phase extraction method based on SH-Au modified silica gel for the detection of six Sudan dyes in chili powder samples. Talanta, 2017, 165, 18-26. (IF = 4.2)
7. Wenhua Ji, Rihan Sun, Wenjuan Duan, Xiao Wang*, Tao Wang, Yan Mu, Lanping Guo*, Selective solid phase extraction of chloroacetamide herbicides from environmental water samples by amphiphilic magnetic molecularly imprinted polymers, Talanta, 2017, 170, 111-118. (IF = 4.2)
8. Wenhua Ji, Mingming Zhang, Wenjuan Duan, Xiao Wang*, Hengqiang Zhao, Lanping Guo*, Phytic acid-stabilized super-amphiphilic Fe3O4-graphene oxide for extraction of polycyclic aromatic hydrocarbons from vegetable oils, Food Chemistry, 2017, 235, 104–110. (IF = 4.9, top期刊)
9. Wenhua Ji *, Tao Wang, Wei Liu, Feng Liu, Lanping Guo, Yanling Geng, Xiao Wang*, Water-compatible micron-sized monodisperse molecularly imprinted beads for selective extraction of five iridoid glycosides from Cornus officinalis fructus, Journal of Chromatography A, 2017, 1504, 1–8. (IF = 3.9)
10. Wenhua Ji, Mingming Zhang, Huijiao Yan, Hengqiang Zhao, Yan Mu, Lanping Guo, Xiao Wang*, Selective extraction and determination of chlorogenic acids as combined quality markers in herbal medicines using molecularly imprinted polymers based on a mimic template, Analytical and Bioanalytical Chemistry, 2017, 409, 7087–7096. (IF = 3.4)
11. Heng Zhu, Daijie Wang, Lei Wen ,Jinqian Yu ,Yanling Geng ,HengqiangZhao, Xiao Wang*. Preparative separation of quaternary ammonium alkaloids from Caulis Mahoniae by conventional and pH-zone-refining counter-current chromatography. RSC Advances,2016, 6, 83343–83349 (IF = 3.1)
12. Huaizhi Li, Yan Cheng, Hongjing Dong, Xiao Wang*, Jia Li, Qianshan Gao Preparation of salvianolic acid A by the degradation reaction of salvianolic acid B in subcritical water integrated with pH-zone-refining counter-current chromatography, Journal of Chromatography A, 2016, 1468, 42-48 (IF = 4.1)
13. Wenhua Ji, Mingming Zhang, Wei Liu, Xingmin Wang ,Wenjuan Duan, Hongkai Xie ,Xiao Wang*, Development of hydrophilic magnetic molecularly imprinted polymers by directly coating onto Fe3O4 with a water-miscible functional monomer and application in a solid- phase extraction procedure for iridoid glycosides, RSC Advances,2016, 6, 50487–50496 (IF = 3.1)
14. Wenhua Ji, Mingming Zhang, Qianshan Gao, Li Cui, Lizong Chen, and Xiao Wang*, Preparation of hydrophilic molecularly imprinted polymers via bulk polymerization combined with hydrolysis of ester groups for selective recognition of iridoid glycosides. Analytical and Bioanalytical Chemistry, 2016, 408, 5319–5328. (IF = 3.4)
15. Changlei Sun,Feng Liu,Jie Sun,Jia Li,Xiao Wang*, Optimisation and establishment of separation conditions of organicacids from Usnea longissima Ach. by pH-zone-refining counter –current chromatography:Discussion of the eluotropic sequence, Journal of Chromatography A, 2016,1427:96–101(IF = 3.9)
16. Hongkai Xie, Wenhua Ji, Dahui Liu, Wei Liu, Daijie Wang, Ruimin Lv, Xiao Wang*, Surface molecularly imprinted polymers with dummy templates for the separation of dencichine from Panax notoginseng, RSC Advances, 2015, 5: 48885-48892(IF = 3.1)
17. Wenhua Ji , Mingming Zhang , Daijie Wang , Xiao Wang ? , Jianhua Liu a , Luqi Huang, Superhydrophilic molecularly imprinted polymers based on a water-soluble functional monomer for the recognition of gastrodin in water media. J. Chromatogr. A, 2015, 1425, 88-96(IF = 3.9)
18. Wenhua Ji , Xiuli Ma,Jinghua Zhang , Hongkai Xie,Feng Xiao, Xiao Wang ?, Preparation of the high purity gingerols from ginger by dummy molecularly imprinted polymers, J. Chromatogr. A, 2015, 1387, 24 – 31(IF = 3.9)
19. Changlei Suna,b, Jia Lib, Xiao Wanga,*, Wenjuan Duana, Tianyou Zhanga, Yoichiro Itoc,**.JPreparative separation of quaternary ammonium alkaloids fromCoptis chinensis Franch by pH-zone-refining counter-currentchromatography.Journal of Chromatography A, 2014, 1370, 156–161. (IF = 3.9)
20. Wenhua Jia,1, Xiuli Mab,1, Hongkai Xieb, Lingxiao Chenb, Xiao Wanga,b,*,Hengqiang Zhaoa, Luqi Huangc,**. Molecularly imprinted polymers with synthetic dummy template forsimultaneously selective removal and enrichment of ginkgolic acidsfrom Ginkgo biloba L. leaves extracts .Journal of Chromatography A, 2014, 1368, 44–51. (IF = 3.9)
專著:
1.pH-區(qū)帶逆流色譜分離技術及應用, 化學工業(yè)出版社, 主編
2.高速逆流色譜技術,化學工業(yè)出版社,,主編
3. Natural Products Extraction --Principle and Applications, The Royal Society of Chemistry, 參編
部分獎項:
1. 國家科技進步獎二等獎“,,第5位,2011年度
2. 山東省科技進步獎一等獎,第1位,,2016年度
3. 山東省科技進步獎二等獎,,第2位,2013年度
4. 山東省科技進步獎二等獎,,第4位,,2011年度
5. 山東省科技進步獎二等獎,第4位,,2011年度
6. 山東省科技進步獎三等獎,,第1位,2012年度
7. 山東省科技進步獎三等獎,,第2位,,2010年度
8. 中國分析測試協(xié)會科學技術獎一等獎,第1位,,2015年度
9. 中國分析測試協(xié)會科學技術獎二等獎,,第1位,2011年度